Medial temporal lobe glutathione concentration in first episode psychosis: A 1H-MRS investigation

SJ Wood; GE Berger; RM Wellard; TM Proffitt; M McConchie; M Berk; PD McGorry; C Pantelis

Journal article

Medial temporal lobe glutathione concentration in first episode psychosis: A 1H-MRS investigation

SJ Wood, GE Berger, RM Wellard, TM Proffitt, M McConchie, M Berk, PD McGorry, C Pantelis

Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2009

DOI: 10.1016/j.nbd.2008.11.018

Abstract

Glutathione (GSH) is implicated in the pathophysiology of schizophrenia. Previous brain spectroscopy studies, however, have been inconsistent, and there is little data available from first episode psychosis patients. This study compared brain GSH in a first episode cohort (n = 30) to controls (n = 18), using magnetic resonance spectroscopy (MRS), examining a temporal lobe voxel. Short-echo (TE 30 ms) acquisition proton MRS was performed on a 3T clinical magnetic resonance scanner. Comparison of the first-episode and control groups' GSH concentrations revealed a significant main effect of group (F1,46 = 4.7, p = 0.035), but no main effect of hemisphere (F1,46 = 2.3, p = 0.137) or group-by-sid..

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University of Melbourne Researchers

Stephen Wood Author

Michael Berk Author

Patrick McGorry Author

Christos Pantelis Author

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Grants

Funding Acknowledgements

This work was supported by two NH&MRC project grants (ID: 145627 & 209062), a NH&MRC program grant (ID: 350241), and the Colonial Foundation, Melbourne, Australia. Dr. Wood is the recipient of a National Health and Medical Research Council Career Development Award and a NARSAD Young Investigator Award. Dr. Berger was supported by a Swiss National Science Foundation young investigator award, and a Margaret and Walter Lichtenstein Foundation award (University of Basel).